Thymidylate synthase (TS) gene copy number in NSCLC

Authors :: J. Ranger-Moore
Rafal Dziadziuszko
Shalini Singh
Katarzyna Dziadziuszko
Fred R. Hirsch
Jacek Jassem
Barbara Szostakiewicz
Murry W. Wynes
Source :: Journal of Clinical Oncology. 28:e21063-e21063
Publication Year :: 2010
Publisher :: American Society of Clinical Oncology (ASCO), 2010.
Abstract: e21063 Background: Studies suggest that high TS expression associates with poor prognosis and confers resistance to antifolates, particularly pemetrexed. TS is essential for de novo production of d...