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Expression of estrogen receptors in gastric cancer and their clinical significance

Authors :
Seong Heum Park
Jong Han Kim
Seungjoo Kim
Woo Sang Ryu
Sungsoo Park
Jun Won Um
You Jin Jang
Young Jae Mok
Chong Suk Kim
Source :
Journal of Surgical Oncology. 106:456-461
Publication Year :
2012
Publisher :
Wiley, 2012.

Abstract

Backgrounds and Objectives The male predominance of gastric cancer suggests that female sex hormones may have a protective effect against gastric cancer. We evaluated the expression of estrogen receptors in gastric cancer tissue and cells and the clinical significance of ER-β expression in gastric cancer. Method ER-α, ER-β proteins extracted from normal stomach, gastric cancer tissues, and cultured gastric cancer cells (KATO-III, mkn28, mkn45, and mkn74) were assessed by Western blot analysis. The clinical significance of ER-β was explored using tissue microarray methods and immunohistochemical staining of specimens from 148 gastric cancers. Results Both ER-α and β protein expression were noted in normal and gastric cancer tissues. However, in cultured gastric cells, only ER-β was noted in mkn28 and mkn74. Of 148 gastric cancers, 67 (45.3%) were ER-β positive. The ER-β positive group was associated with lower tumor stage, Lauren's intestinal type, negative perineural invasion, and free of recurrence. The ER-β positive group had a better 3-year survival compared with the negative group in survival analysis. Conclusion Our results suggest that the presence of ER-β in gastric cancer could have a protective effect against invasiveness of gastric cancer. Further studies are needed to clarify the role of ER-β in gastric cancers. J. Surg. Oncol. 2012; 106:456–461. © 2012 Wiley Periodicals, Inc.

Details

ISSN :
00224790
Volume :
106
Database :
OpenAIRE
Journal :
Journal of Surgical Oncology
Accession number :
edsair.doi...........940cd53ab65791a27a9929f908b59f4a