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Effectiveness of the curative complex consisting of photodynamic therapy, intravenous laser irradiation and local laser irradiation aimed at correcting hemostatic parameters at the initial stages of squamous cell skin cancer
- Source :
- Laser Medicine. 24:9-17
- Publication Year :
- 2021
- Publisher :
- Skobelkin State Scientific Center of Laser Medicine, 2021.
-
Abstract
- Purpose. To assess the effectiveness of curative complex consisting of photodynamic therapy (PDT) + intravenous laser blood irradiation (ILBI) + local tumor irradiation (TR) at hemostatic parameters at the initial stages of squamous cell skin cancer (SCSC).Material and methods. The present work analyzes SCSC course in 185 patients who had outpatient and inpatient treatment in medical institutions of cities Engels and Saratov in 2015–2019. 129 (69.7%) males and 56 females (31.2%). Patients were divided into three groups. Group I – 74 (40%) patients who had combined treatment: surgery with wide tumor excision under intravenous anesthesia + PDT + ILBI + TR; Group II – 111 (60%) patients who had only surgical treatment. Group III was created for controlling and comparing the obtained laboratory parameters; it included 17 patients without established pathology.Results. It was found out that hemostatic disorders in SCSC are characterized by increased activity of AT III and vWF and by simultaneous decrease of tPA-PAI-1 complex as well as by increased activity of VIIIa factor and resistance of Va factor – indices which indicate dysfunction of endothelial vascular wall. Combination of PDT + ILBI + TR prior to surgical treatment in patients with squamous cell skin cancer at the initial stages of the disease allow to normalize homeostatic indices and reduce the number of complications.Conclusion. 1. Squamous cell skin cancer at the initial stages changes the hemostatic system. 2. Effects of SCSC mechanism may be characterized as follows: damage of the endothelium vascular wall which is confirmed by endothelin increase; it results in vasoconstriction and increased blood procoagulant activity and, ultimately, in changes of hemostatic parameters. 3. Combination of PDT + ILBI + TR applied before surgery in patients with squamous cell skin cancer at the initial stages of the disease normalizes homeostatic indices and reduces the number of complications.
- Subjects :
- medicine.medical_specialty
Endothelium
business.industry
medicine.medical_treatment
Photodynamic therapy
Squamous cell skin cancer
Gastroenterology
Blood irradiation therapy
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
medicine.anatomical_structure
Intravenous anesthesia
030220 oncology & carcinogenesis
Internal medicine
medicine
medicine.symptom
Endothelin receptor
business
Vasoconstriction
Homeostasis
Subjects
Details
- ISSN :
- 26868644 and 20718004
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Laser Medicine
- Accession number :
- edsair.doi...........9367fc97174d2163e9d48f825067f7b9