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Summary Three aspects of integrated disease management are considered. The first is the epidemiological synergism that can be derived through combining management tactics, and through disease management at regional scales. Field studies with potato late blight are used to demonstrate epidemiological impacts of integrating host resistance, fungicides, host density, and host genetic diversity. The importance of considering spatial scale and regional disease management are demonstrated with examples of cultivar mixtures in three different pathosystems. The second aspect is the potential for integrated management to increase the durability of resistance, e.g., through reduction of pathogen population size and imposition of disruptive selection. At this point in time, most information on this topic is limited to arguments of logic and to the results of mathematical models; empirical data are largely lacking. We suggest that current theoretical approaches need to be supplemented with inclusion of more complex processes, such as the effect of fitness modifiers in pathogen populations and the influence of quantitative adaptation of pathogens to their hosts. The third aspect is integration of resistance into overall crop management, including factors such as the balance between yield potential and disease resistance and the management of genotype x environment interaction. Such integration will increase the likelihood that farmers will utilize durable resistance, and will be demonstrated with examples from wheat production in the Pacific Northwest region of the USA.