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Decreased expression of elastin and lysyl oxidase family genes in urogenital tissues of aging mice
- Source :
- Journal of Obstetrics and Gynaecology Research. 40:1998-2004
- Publication Year :
- 2014
- Publisher :
- Wiley, 2014.
-
Abstract
- Aim This study aims to investigate the expression levels of elastin and lysyl oxidase (LOX) family members in the urogenital tissues of natural aging mice and accelerated ovarian aging mice. Method Uteri, vaginas and bladders were harvested from 18-month-old female mice and accelerated ovarian aging mice developed by chemotherapeutic agents. Untreated 3-month-old female mice were used as controls. The expression levels of elastin and LOX family members were determined by real-time polymerase chain reaction and western blot. Results Compared with untreated young female mice, the expression of elastin and LOX family members significantly decreased both in natural aging mice and accelerated ovarian aging mice. Conclusion Aging is a high-risk factor for pelvic floor disorders. The failure of elastic fiber synthesis and assembly due to the decline in expression levels of elastin and LOX family members during aging may explain the molecular mechanism causing pelvic floor disorders.
- Subjects :
- medicine.medical_specialty
Pathology
integumentary system
biology
medicine.diagnostic_test
Genitourinary system
Obstetrics and Gynecology
Lysyl oxidase
Pelvic Floor Disorders
law.invention
Endocrinology
medicine.anatomical_structure
Western blot
law
Internal medicine
biology.protein
medicine
Gene
Elastin
Polymerase chain reaction
Elastic fiber
Subjects
Details
- ISSN :
- 13418076
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Journal of Obstetrics and Gynaecology Research
- Accession number :
- edsair.doi...........92ae047ae28edd4621d0b568e390acee