ChemInform Abstract: Recent Advances on Asymmetric Nitroso Aldol Reaction

The reaction of aromatic nitroso derivatives with enolizable carbonyl compounds (nitroso aldol reaction) to give either α-hydroxyamino or α-aminoxy carbonyl compounds is an important synthetic method. This review illustrates the recent advances in rendering the process regio- and enantioselective as well as catalytic. By employing metal and organic catalysts a range of α-amino (α-oxyamination) and α-hydroxy (α-aminoxylation) carbonyl derivatives can be generated with total regioselectivity and high levels of enantiomeric excess. 1 Introduction 2 Metal-Catalyzed Reactions 3 Organocatalyzed Reactions 4 Enamine Metal-Free Reactions 5 Concluding Remarks