A comparative experimental study of silicone gel and bioplastique

Bioplastique, a biphasic polymer of textured dimetylpolysiloxane is reported to be useful in filling small soft tissue defects. The microparticles range in size from 100 to 600 p and are suspended in a hydrogel carier from the family of the plasdones. The bioexcretable gel component is rapidly phagocytized and replaced by fibrin-like matrix with in a few days. In this study it is aimed to observe the local and systemic effects of Bioplastique and gel silicone in comparison. Our study in rabbit ears has shown that Bioplastique caused severe foreign body reaction in injection site and showed no migration to lymph nodes. On the other hand, silicone gel caused fibrous encapsulation and showed migration to lymph nodes, and formation of granulomatous reaction.