ChemInform Abstract: p-Nitrophenyl 1,5-Dithio-α-L-fucopyranoside: A Novel Sulfur Based Fucosidase Inhibitor

Five 5-thio-α- l -fucopyranosyl derivatives were prepared and examined as inhibitors of the α- l -fucosidase from bovine epididymis. The inhibitory activities of the fucosides strongly depend on the hydrophobicity of the aglycon. The best inhibition ( K i = 3.3 μM) was obtained with p -nitrophenyl 1,5-dithio-α- l -fucopyranoside.