Back to Search
Start Over
Protecting the Kidney in Liver Transplant Recipients: Practicee-Based Recommendations From the American Society of Transplantation Liver and Intestine Community of Practice
- Source :
- American Journal of Transplantation. 16:2532-2544
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Both acute and chronic kidney disease are common after liver transplantation and result in significant morbidity and mortality. The introduction of the Model for End-stage Liver Disease score has directly correlated with an increased prevalence of perioperative renal dysfunction and the number of simultaneous liver-kidney transplantations performed. Kidney dysfunction in this population is typically multifactorial and related to preexisting conditions, pretransplantation renal injury, perioperative events, and posttransplantation nephrotoxic immunosuppressive therapies. The management of kidney disease after liver transplantation is challenging, as by the time the serum creatinine level is significantly elevated, few interventions affect the course of progression. Also, immunological factors such as antibody-mediated kidney rejection have become of greater interest given the rising liver-kidney transplant population. Therefore, this review, assembled by experts in the field and endorsed by the American Society of Transplantation Liver and Intestine Community of Practice, provides a critical assessment of measures of renal function and interventions aimed at preserving renal function early and late after liver and simultaneous liver-kidney transplantation. Key points and practice-based recommendations for the prevention and management of kidney injury in this population are provided to offer guidance for clinicians and identify gaps in knowledge for future investigations.
- Subjects :
- Nephrology
medicine.medical_specialty
medicine.medical_treatment
Population
Renal function
030230 surgery
Liver transplantation
03 medical and health sciences
Liver disease
0302 clinical medicine
Internal medicine
medicine
Immunology and Allergy
Pharmacology (medical)
Intensive care medicine
education
Transplantation
Kidney
education.field_of_study
business.industry
medicine.disease
medicine.anatomical_structure
030211 gastroenterology & hepatology
business
Kidney disease
Subjects
Details
- ISSN :
- 16006135
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- American Journal of Transplantation
- Accession number :
- edsair.doi...........921fbf5f831cda0bf8f53d35a6df62e7