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Toward disease modification in multiple system atrophy: Pitfalls, bottlenecks, and possible remedies
- Source :
- Movement Disorders. 31:235-240
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- Multiple system atrophy has recently attracted increased attention in basic and clinical research. Understanding of key pathophysiological mechanismshas improved; and, in the past decade, the first clinical trials aiming at diseasemodification were conducted. However, there is still no established interventional therapy available. In this review, the authors summarize recent advances, discuss bottlenecks and possible pitfalls of previous interventional studies, and suggest future research avenues.
- Subjects :
- 0301 basic medicine
Interventional therapy
medicine.medical_specialty
business.industry
medicine.disease
Clinical trial
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Atrophy
Clinical research
Neurology
Disease modification
medicine
Neurology (clinical)
Intensive care medicine
business
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 08853185
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Movement Disorders
- Accession number :
- edsair.doi...........91f6478f7279e74d28147c15d0c847e0