Synthesis of the Plasma Proteins

Various methods of demonstrating the sites of plasma protein synthesis have been reported. Fundamentally, after the amino acids labelled with a radioactive isotope are added to a particular system and incubated for a certain period, then radioactivity is detected in particular proteins which increase by synthesis in the system studied. This procedure was first introduced by Peters and Anfinsen.110) That is, 14CO2 was added to the liver section of chickens, and albumin was separated after a certain time in which radioactive carbon was found to exist. Thus, it was proved that albumin is synthesized in the liver.