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Cinerols, Nitrogenous Meroterpenoids from the Marine Sponge Dysidea cinerea
- Source :
- Journal of Natural Products. 82:2586-2593
- Publication Year :
- 2019
- Publisher :
- American Chemical Society (ACS), 2019.
-
Abstract
- Eleven new nitrogenous meroterpenoids, cinerols A-K (1-11), were isolated from the marine sponge Dysidea cinerea collected in the South China Sea, and their structures were determined by detailed spectroscopic analysis. Cinerols A (1) and B (2) feature a rare 5H-pyrrolo[1,2a]benzimidazole moiety, while cinerols C-G (3-7) are examples of rare meroterpene benzoxazoles. The cinerols are noncytotoxic to human melanoma A375 cells at the concentration of 32 μM; however, selected cinerols exhibit moderate inhibitory activity against one or more of protein-tyrosine phosphatase 1B, ATP-citrate lyase, and SH2 domain-containing phosphatase-1 with IC50 values of 2.8-27 μM.
- Subjects :
- Pharmacology
Meroterpene
Benzimidazole
South china
ATP citrate lyase
biology
010405 organic chemistry
Stereochemistry
Organic Chemistry
Phosphatase
Pharmaceutical Science
Lyase
biology.organism_classification
01 natural sciences
0104 chemical sciences
Analytical Chemistry
010404 medicinal & biomolecular chemistry
chemistry.chemical_compound
Sponge
Complementary and alternative medicine
chemistry
Drug Discovery
Molecular Medicine
Moiety
Subjects
Details
- ISSN :
- 15206025 and 01633864
- Volume :
- 82
- Database :
- OpenAIRE
- Journal :
- Journal of Natural Products
- Accession number :
- edsair.doi...........914f42dcad811ffc44b132e066a38a2c