Cytokine expression profile in hospitalized children with herpes simplex virus-1 infection

Aim: We aim to demonstrate the cytokine expression profile of children with herpes simplex virus-1 (HSV-1) infection. Methods: One hundred eighty three children with acute encephalitis were enrolled in this study. Out of those with HSV-1, multiple cytokines were measured. Results: Cytokine analysis of 13 HSV-1-infected patients revealed that IL-8 and granulocyte macrophage colony stimulating factor accumulated at significantly higher levels than macrophage inflammatory protein-1β in the cerebrospinal fluid. Additionally, IFN-γ in serum and cerebrospinal fluid was positively correlated with course of illness, while IL-10 in cerebrospinal fluid was negatively correlated with course of illness. Conclusion: Granulocyte macrophage colony stimulating factor, IL-8, macrophage inflammatory protein-1β, IFN-γ and IL-10 are involved in the HSV-1 immune response and pathogenesis.