e0653 Level change of plasma BNP and the relationships to the left ventricular aneurysm formation and cardiac performance in patients with acute myocardial infarction

Objective To investigate the change of brain natriuretic peptide (BNP) in plasma and the relationships with the left ventricular aneurysm (LVA) and cardiac performance in acute myocardial infarction (AMI) patients using left ventriculography (LVG). Methods A total of 64 patients with primary anterior AMI accompanied LVA diagnosed by LVG were enrolled in this study and divided into LVA group (33 patients) and non-LVA group (31 patients). Plasma BNP was measured. At the immediately after PCI and 6th month after AMI, the parameters of LVEDVI, LVESVI, LVEF, WMS and LVEDP were measured by LVG. The main adverse cardiac events (MACE) were recorded during 24 week after PCI. Results The peak value of plasma BNP in LVA group was higher and the arrived time of peak values of peak time of plasma BNP was earlier than those in the non-LVA group (p Conclusions The value of plasma BNP in the AMI patients with LVA was higher than that with non-LVA, and significantly correlated with left ventricular remodelling status and homodynamic change. It is indicated that the over secretion of BNP is involved in the left ventricular remodelling and the process of LVA formation.