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DNA radiosensitization by terpyridine-platinum: damage induced by 5 and 10 eV transient anions

Authors :
Liangde Ouyang
Hong Lin
Puxiang Zhuang
Yu Shao
Meysam Khosravifarsani
Brigitte Guérin
Yi Zheng
Léon Sanche
Source :
Nanoscale. 15:3230-3242
Publication Year :
2023
Publisher :
Royal Society of Chemistry (RSC), 2023.

Abstract

The intercalation of the chemotherapeutic drug terpyridine-platinum within the G-quadruplex structure of DNA sensitizes cancer cells to the low energy electrons produced by ionizing radiation during radiotherapy.

Subjects

Subjects :
General Materials Science

Details

ISSN :
20403372 and 20403364
Volume :
15
Database :
OpenAIRE
Journal :
Nanoscale
Accession number :
edsair.doi...........90889eaa5bfdfa26f87cf71291f95bad