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Micronuclei and other nuclear abnormalities in phorate exposed fish, Channa punctatus
- Source :
- Journal of Environmental Biology. 42:1221-1231
- Publication Year :
- 2021
- Publisher :
- Triveni Enterprises, 2021.
-
Abstract
- Aim: The present study aims to establish morphology-based nuclear abnormalities (NAs) including micronuclei (MN) as effective and sensitive genotoxic endpoint biomarkers in fish against the sub-lethal exposure of phorate. Methodology: Fish, Channa punctatus (35 ± 3.0 g; 14.5 ± 1.0 cm) were randomly exposed in two sets, treated group 1 and 2 (0.0375 mg l-1 and 0.075 mg l-1 of phorate, respectively) along with a simultaneous control (0 mg l-1). The blood was sampled after 30 days. Results: A significant (p < 0.05) induction in reactive oxygen species (ROS) coupled with elevated frequency of blood cells showing micronuclei along with the gross appearance of notched nuclei, curved nuclei, blebbed nuclei, kidney-shaped nuclei, V-shaped nuclei, nuclear buds, nucleoplasmic bridges, dumbbell nuclei, and condensed/rounded nuclei were recorded in a dose-dependent manner. Interpretation: A significant (p < 0.05) induction in reactive oxygen species (ROS) coupled with elevated frequency of blood cells showing micronuclei along with the gross appearance of notched nuclei, curved nuclei, blebbed nuclei, kidney-shaped nuclei, V-shaped nuclei, nuclear buds, nucleoplasmic bridges, dumbbell nuclei, and condensed/rounded nuclei were recorded in a dose-dependent manner.
Details
- ISSN :
- 23940379 and 02548704
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- Journal of Environmental Biology
- Accession number :
- edsair.doi...........900a5f9e8a7f6dffa248b1569ea81b6d