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Inertial Migration of Cancer Cells in a Microfluidic Device

Authors :
Takefumi Yoshimoto
Yohsuke Imai
Hironori Ueno
Keiko Numayama-Tsuruta
Takuji Ishikawa
Noriaki Matsuki
Tatsuya Tanaka
Takami Yamaguchi
Source :
Micro and Nano Flow Systems for Bioanalysis ISBN: 9781461443759
Publication Year :
2012
Publisher :
Springer New York, 2012.

Abstract

The circulating tumor cell (CTC) test is used to evaluate the condition of breast cancer patients by counting the number of cancer cells in peripheral blood samples. Although microfluidic systems to detect or separate cells using the inertial migration effect may be applied to this test, the hydrodynamic forces acting on cancer cells are incompletely understood. In this chapter, we explain the inertial migration of cancer cells in microchannels. We also explain fabrication techniques of microchannels used in the experiments. By measuring the cell migration probability, we examined the effects of cell deformability and variations in cell size on the inertial migration of cancer cells. The results clearly illustrate that cancer cells can migrate towards equilibrium positions in the similar manner with rigid spheres. These results will be important for the design of microfluidic devices for the CTC test.

Details

ISBN :
978-1-4614-4375-9
ISBNs :
9781461443759
Database :
OpenAIRE
Journal :
Micro and Nano Flow Systems for Bioanalysis ISBN: 9781461443759
Accession number :
edsair.doi...........8fecf7043855f9868e3f130d0b480824
Full Text :
https://doi.org/10.1007/978-1-4614-4376-6_2