Combined Effect of (–)-Vesamicol and (+)-Tubocurarine on Endplate Current Amplitude in Rat Skeletal Muscle at High Frequencies of Nerve Stimulation

(−)-Vesamicol produces a rundown in endplate current amplitude at high frequencies of motor nerve stimulation which appears to be due to an ability of the compound to impair transmitter mobilization. This implicates a role for vesicular ACh in mobilization at high frequencies of nerve stimulation.