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Survival Analysis of Drug Combinations Using a Hazards Model with Time-Dependent Covariates
- Source :
- Biometrics. 36:537
- Publication Year :
- 1980
- Publisher :
- JSTOR, 1980.
-
Abstract
- Hazard functions in cancer chemotherapeutic situations may not be proportional, so a nonproportional hazard model has been developed. The dose-response surface is explored by regression analysis of experimental data, and after the estimation of the underlying hazard function the quality of the fit of the model is assessed. Further, treatment levels may be optimized, and estimated survival distributions can be plotted for any treatment combination. In an example of two-drug treatment of murine L1210 leukemia, statistically significant nonproportionality is determined. Analysis permits extraction of potentially important information on drug interrelationships, which has been previously unavailable.
- Subjects :
- Statistics and Probability
Drug
Hazard (logic)
General Immunology and Microbiology
Applied Mathematics
media_common.quotation_subject
Regression analysis
General Medicine
Leukemia L1210
General Biochemistry, Genetics and Molecular Biology
Combined treatment
Statistics
Covariate
Hazard model
General Agricultural and Biological Sciences
Survival analysis
media_common
Mathematics
Subjects
Details
- ISSN :
- 0006341X
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Biometrics
- Accession number :
- edsair.doi...........8fa5e1fb15e3a60dfc6405bb076cc72a