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Outcomes of Premature Ventricular Contraction–Cardiomyopathy in the Veteran Population

Authors :
Hans Moore
Jordana Kron
Kenneth A. Ellenbogen
Susan G. Fisher
Karoly Kaszala
Santosh K. Padala
Jose F. Huizar
Jayanthi N. Koneru
Steven N. Singh
Frederick V. Ramsey
Alex Y. Tan
Source :
JACC: Clinical Electrophysiology. 7:380-390
Publication Year :
2021
Publisher :
Elsevier BV, 2021.

Abstract

Objectives This study sought to assess the rate and outcomes of premature ventricular contractions (PVC)–cardiomyopathy from the CHF-STAT (Survival Trial of Antiarrhythmic Therapy in Congestive Heart Failure) trial, a population with cardiomyopathy (left ventricular [LV] ejection fraction of 10 PVCs per hour). Background PVCs are associated with heart failure and PVC-cardiomyopathy. The prevalence of PVC-cardiomyopathy and outcome benefits of PVC suppression are not clear. Methods A secondary analysis of the CHF-STAT study was performed to compare the rate of successful PVC suppression (≥80% PVC reduction), LV recovery (defined as improvement in LV ejection fraction of ≥10% points), and PVC-cardiomyopathy between amiodarone and placebo groups at 6 months. PVC-cardiomyopathy was defined if both PVC reduction of ≥80% and LV ejection fraction improvement of ≥10% were present at 6 months. Cardiac events (death or resuscitated cardiac arrest) were compared between PVC-cardiomyopathy versus non–PVC-cardiomyopathy during a 5-year follow-up. Results The rates of successful PVC suppression and LV recovery were significantly higher in the amiodarone (72% and 39%, respectively) when compared to the placebo group (12% and 16%, respectively; p Conclusions The overall prevalence of PVC-cardiomyopathy in the CHF-STAT study was significant regardless of ischemic substrate (29%, overall population; 41%, nonischemic cardiomyopathy). Treatment of PVC-cardiomyopathy with amiodarone is likely to improve survival in this high-risk population.

Details

ISSN :
2405500X
Volume :
7
Database :
OpenAIRE
Journal :
JACC: Clinical Electrophysiology
Accession number :
edsair.doi...........8f86aef83fbf7d94990e444a3cc15a8e