Linalool Suppresses Proliferation and Promotes Apoptosis in Gastric Cancer Cells via Activation of Reactive Oxygen Species-Mediated P53 Pathway

The role of linalool in gastric cancer has been examined by measuring its effects on cell cytotoxicity, apoptosis, and accumulation of reactive oxygen species as well as markers of oxidative stress. In a dose-dependent fashion, linalool suppressed the viability of gastric cancer cells and increased accumulation of reactive oxygen species with a concomitant increase in malondialdehyde, cleavage of caspase 3 and p53 and decrease in superoxide dismutase and glutathione peroxidase. N-acetyl cysteine, a scavenger of reactive oxygen species reduced the effects of linalool on gastric cancer cells. In conclusion, linalool suppresses cell viability and promotes cell apoptosis of gastric cancer cells via activation of reactive oxygen species-mediated p53 pathway suggesting that linalool might serve as a potential anti-cancer agent.