COMPARISON OF JNJ9375, A THROMBIN EXOSITE 1-DIRECTED ANTIBODY, WITH APIXABAN FOR THROMBOPROPHYLAXIS AFTER ELECTIVE KNEE REPLACEMENT SURGERY: TEXT-TKR STUDY

Authors :: Takeshi Fuji
Charles Francis
Robin S. Roberts
Jeffrey I. Weitz
Michael R. Lassen
Maureen Johnson
Gary Peters
Gary E. Raskob
Juliane Bernholz
Annelise Segers
John Strony
Michael Lee
Renee Swaim
Source :: Journal of the American College of Cardiology. 73:2047
Publication Year :: 2019
Publisher :: Elsevier BV, 2019.
Abstract: JNJ9375 is a monoclonal antibody against exosite-1 on thrombin. JNJ9375 inhibits thrombin binding to its substrates but not its catalytic activity. Consequently, JNJ9375 may attenuate thrombosis without affecting hemostasis. To test this hypothesis, JNJ9375 and apixaban were compared in the TEXT-TKR

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