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PD7-05 VIRAL CYSTITIS INDUCED BY CROSS-INFECTION FROM THE COLON – POTENTIAL MECHANISM FOR INTERSTITIAL CYSTITIS
- Source :
- Journal of Urology. 193
- Publication Year :
- 2015
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2015.
-
Abstract
- INTRODUCTION AND OBJECTIVES: Many urologic conditions are associated with dysfunction of autonomic bladder innervation. A precise understanding of the anatomical relationship of the bladder neck and its autonomic nervous system could substantially improve treatment modalities. Currently there is no comprehensive model that provides a detailed three-dimensional (3D) view of bladder neck innervation. Therefore, we sought to create a 3D reconstruction of autonomic nervous tissue innervating the bladder neck using male and female cadaver histopathology. METHODS: We obtained intact pelvic tissues from a male and female cadaver. Axial cross-sections of the bladder neck were generated at 3e5mm intervals and stained for S100 protein. Distances between autonomic nerves and bladder mucosa were recorded. Nerve tracings were manually demarcated and imported into SolidWorks (Waltham, MA, USA) and Blender (Amsterdam, Netherlands) software programs to generate 3D reconstructions of autonomic nerve anatomy. RESULTS: Longitudinal and circular nerve tracings were successfully demarcated and converted into a 3D image reconstruction. We successfully precisely characterized anatomic nerve distributions. Axial cross-sections and 3D images showed that autonomic innervation was highly concentrated in the posterior aspect of the bladder neck in both male and female bladder specimens (Figures 1 and 2). The mean distances between autonomic nerve tissue and the bladder mucosa was 1.15mm posteriorly and 4.0mm anteriorly in the male bladder (0.27-2.87 vs. 2.03-6.20, p
- Subjects :
- medicine.medical_specialty
Autonomic nerve
business.industry
Urology
Nervous tissue
Interstitial cystitis
Anatomy
urologic and male genital diseases
medicine.disease
S100 protein
Autonomic nervous system
Neck of urinary bladder
medicine.anatomical_structure
Cadaver
Medicine
Histopathology
business
Subjects
Details
- ISSN :
- 15273792 and 00225347
- Volume :
- 193
- Database :
- OpenAIRE
- Journal :
- Journal of Urology
- Accession number :
- edsair.doi...........8ea3ddbe643001c72207f3b0295650cd