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Neuroendocrine differentiation in the progression of prostate cancer
- Source :
- International Journal of Urology. 16:37-44
- Publication Year :
- 2008
- Publisher :
- Wiley, 2008.
-
Abstract
- Neuroendocrine (NE) cells originally exist in the normal prostate acini and duct, regulating prostatic growth, differentiation and secretion. Clusters of malignant NE cells are found in most prostate cancer (PCa) cases. NE differentiation (NED) is the basic character of the prostate, either benign or malignant. NE cells hold certain peptide hormones or pro-hormones, which affect the target cells by endocrine, paracrine, autocrine and neuroendocrine transmission in an androgen-independent fashion due to the lack of androgen receptor. NED is accessed by immunohistochemical staining or measurement of serum levels of NE markers. The extent of NED is associated with progression and prognosis of PCa. Chromogranin A (CGA) is the most important NE marker. In metastatic PCa, pretreatment serum CGA levels can be a predictor for progression and survival after endocrine therapy. It is recommended to measure longitudinal change in serum CGA. The NE pathway can also be a therapeutic target.
- Subjects :
- Oncology
PCA3
endocrine system
medicine.medical_specialty
biology
business.industry
Urology
Chromogranin A
medicine.disease
Neuroendocrine differentiation
Androgen receptor
Paracrine signalling
Prostate cancer
medicine.anatomical_structure
Prostate
Internal medicine
medicine
biology.protein
Autocrine signalling
business
Subjects
Details
- ISSN :
- 09198172
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- International Journal of Urology
- Accession number :
- edsair.doi...........8e80a50a433218a840e48e13838813ab