ChemInform Abstract: A Selective C-H Insertion/Olefination Protocol for the Synthesis of α-Methylene-γ-butyrolactone Natural Products

A regio- and stereoselective one-pot C–H insertion/olefination protocol has been developed for the late stage installation of α-methylene-γ-butyrolactones into conformationally restricted cyclohexanol-derivatives. The method has been successfully applied in the total synthesis of eudesmanolide natural product frameworks, including α-cyclocostunolide.