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On the persistence of mouse urine odour to human observers: a review
- Source :
- Flavour and Fragrance Journal. 31:267-282
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- To the human nose, mice produce unique, persistent and potent odour which is widely assumed to be derived mainly from their urine. In this review, we discuss why the mouse odour is so potent and long-lasting to the human nose. Sensory and chemical analyses have revealed that 2-sec-butyl-4,5-dihydrothiazole (SBT) was the major mousy odorant and present almost exclusively in male urine. It is not depleted from urine even after repeated headspace or solvent extractions since its majority is tightly bound to the major urinary proteins (MUPs) in male mouse urine that serve to control the release. The urinary concentration of SBT is estimated to be around several hundred parts per million when the binding of SBT to MUPs is considered, while its human olfactory threshold is estimated to be approximately at the parts per billion level. Therefore, the strikingly persistent quality of mouse urine odour, mainly contributed by SBT, is explained by its low human olfactory threshold, its presence in urine at a high concentration, and its delayed release by MUPs. Copyright © 2016 John Wiley & Sons, Ltd.
- Subjects :
- 0301 basic medicine
Chromatography
030102 biochemistry & molecular biology
Major urinary proteins
Chemistry
Physiology
General Chemistry
Urine
Persistence (computer science)
03 medical and health sciences
Human nose
030104 developmental biology
medicine.anatomical_structure
Olfactory threshold
medicine
Mouse Urine
Urinary concentration
Food Science
Subjects
Details
- ISSN :
- 08825734
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Flavour and Fragrance Journal
- Accession number :
- edsair.doi...........8e2dc911d3ebf66d266a708eddce3e78
- Full Text :
- https://doi.org/10.1002/ffj.3316