PI3K/AKT/ENOS/HSP70 MEDIATES ATORVASTATIN POST-CONDITIONING AGAINST MYOCARDIAL ISCHAEMIA-REPERFUSION INJURY IN TYPE 2 DIABETIC RATS

Objectives group Methods group Results Compared with I/R group, different dosage (0.1, 0.5, 1.0 or 2.0 mg/kg) of atorvastatin intervention significantly decreased IS (p 0.05), cTnT (p>0.05), Flameng score (p>0.05) as well as myocardial expression of phosphorylated AKt (p>0.05), phosphorylated eNOS (p>0.05) and HSP70 (p>0.05) between groups. Conclusions Our data suggests that activation of the upstream PI3K-Akt-eNOS pathway and up regulation of the downstream protein HSP70 contribute to atorvastatin post conditioning cardio-protection in type 2 diabetic rat.