CRT-600.02 8-Oxoguanine Glycosylase 1 Expression Is Up-regulated in Non ST-Elevation Myocardial Infarction and Correlates With Atherosclerotic Fibrous Cap Thickness

Authors :: Nikunj Shah
Lisiane B. Meira
Michael Mahmoudi
Source :: JACC: Cardiovascular Interventions. 10:S52
Publication Year :: 2017
Publisher :: Elsevier BV, 2017.
Abstract: 8-oxoguanine glycosylase (OGG1) is primarily involved in base excision repair (BER) by excising 8-oxoguanine, a mutagenic by-product of reactive oxygen species exposure. Increased markers of DNA damage/repair have been identified in atherosclerotic plaques, however their effects on plaque stability

Subjects :: chemistry.chemical_classification
Reactive oxygen species
business.industry
DNA damage
Fibrous cap
Base excision repair
Molecular biology
8-Oxoguanine
chemistry.chemical_compound
medicine.anatomical_structure
chemistry
Downregulation and upregulation
St elevation myocardial infarction
DNA glycosylase
Medicine
Cardiology and Cardiovascular Medicine
business

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