Effects of Hypoxia on Radiation-Responsive Stress-Activated Protein Kinase, p53, and Caspase 3 Signals in TK6 Human Lymphoblastoid Cells

Authors :: Ayelet M. Samuni
Usha Kasid
Eric Y. Chuang
Simeng Suy
William DeGraff
Murali C. Krishna
Angelo Russo
James B. Mitchell
Source :: Cancer Research. 65:579-586
Publication Year :: 2005
Publisher :: American Association for Cancer Research (AACR), 2005.
Abstract: Despite significant evidence of a role of hypoxia in cellular resistance to ionizing radiation–induced toxicity, the underlying molecular mechanisms remain unclear. This study focused on the influence of hypoxia on radiation-induced signals in TK6 human lymphoblastoid cells. Hypoxic (

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