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[Untitled]
- Source :
- Journal of Assisted Reproduction and Genetics. 20:95-100
- Publication Year :
- 2003
- Publisher :
- Springer Science and Business Media LLC, 2003.
-
Abstract
- Purpose: To compare the frequency and the degree of mosaicism in human embryos from Robertsonian translocation (RT) t(13;14) carriers, with embryos from karyotypically normal IVF patients. Methods: FISH analysis of embryos from PGD cycles for RT t(13;14), with probes for chromosomes 13, 14, and 18 (Group I) and of embryos from karyotypically normal IVF patients with probes for chromosomes 13, 18, 21, X, and Y (Group II). Results: The incidence of abnormal mosaic embryos was significantly higher in group I (38/51) as compared with group II (6/45) (χ2: P < 0.01). Furthermore, in group I the percentage of diploid cells per embryo was lower for chromosome 13 and 14 in comparison with 18, while in group II no differences were observed between the five chromosomes analyzed. Conclusions: RT induces a high frequency of mosaicism specifically for the chromosomes implicated in the translocation; the analysis by FISH of two blastomeres is strongly recommended for these patients.
- Subjects :
- Obstetrics and Gynecology
Chromosome
Robertsonian translocation
Chromosomal translocation
Embryo
General Medicine
Blastomere
Biology
medicine.disease_cause
Preimplantation genetic diagnosis
Molecular biology
medicine.anatomical_structure
Reproductive Medicine
embryonic structures
Genetics
medicine
Blastocyst
Genetics (clinical)
Developmental Biology
Chromosome 13
Subjects
Details
- ISSN :
- 10580468
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Journal of Assisted Reproduction and Genetics
- Accession number :
- edsair.doi...........8d7a48e5d2f1f774018daa0728455d4c