Flavonoid Inhibitors of β-Ketoacyl Acyl Carrier Protein Synthase III against Methicillin-Resistant Staphylococcus aureus

E-mail: ymkim@konkuk.ac.krReceived May 23, 2011, Accepted June 15, 2011β-Ketoacyl acyl carrier protei n synthase III (KAS III) initiates fatty acid synthesis in ba cteria and is a key targetenzyme to overcome the antibiotic resistance problem. In our previous study, we found flavonoid inhibitors ofEnterococcus faecalis KAS III and proposed three potent antimicrobial flavonoids against Enterococcusfaecalis and Vancomycin-resistant Enterococcus faecalis with MIC values in the range of 128-512 μg/mL aswell as high binding affinities on the order from 10