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[Untitled]
- Source :
- Bulletin of Experimental Biology and Medicine. 135:48-51
- Publication Year :
- 2003
- Publisher :
- Springer Science and Business Media LLC, 2003.
-
Abstract
- Systemic oral administration of NT-0409, a new synthetic agonist of AMPA subtype glutamate receptor, to rats with chronic partial AF64A-induced deprivation of cholinergic functions improved their learning in a Morris water maze. NT-0409 is close to memantine by the effect on learning and, in contrast to cholinomimetic arisept, ensures longer retention of the developed habit.
- Subjects :
- Agonist
business.industry
medicine.drug_class
Glutamate receptor
Memantine
Morris water navigation task
General Medicine
AMPA receptor
Pharmacology
medicine.disease
General Biochemistry, Genetics and Molecular Biology
Oral administration
medicine
Cholinergic
Alzheimer's disease
business
medicine.drug
Subjects
Details
- ISSN :
- 00074888
- Volume :
- 135
- Database :
- OpenAIRE
- Journal :
- Bulletin of Experimental Biology and Medicine
- Accession number :
- edsair.doi...........8d44ccc2785a6e58f3ddba46c180fa84
- Full Text :
- https://doi.org/10.1023/a:1023493828612