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[Untitled]
- Source :
- Digestive Diseases and Sciences. 48:459-464
- Publication Year :
- 2003
- Publisher :
- Springer Science and Business Media LLC, 2003.
-
Abstract
- Pancreatitis-associated protein (PAP) is almost absent in normal pancreas, but is strongly induced in acute pancreatitis. PAP mRNA is also expressed in cancer cells, including pancreatic ductal adenocarcinoma. However, the clinicopathological significance of PAP in human pancreatic cancer is not clear. We examined PAP expression in pancreatic tissues from individuals with pancreatic ductal adenocarcinoma using immunohistochemistry. PAP was overexpressed in 79% (30 of 38) of pancreatic ductal adenocarcinoma, 19% (7 of 36) of chronic pancreatitis, and 29% (2 of 7) of mucinous cystadenoma. PAP was found in malignant ductular structures in pancreatic carcinomas as well as in benign proliferating ductules and acinar cells in chronic pancreatitis. It was not expressed in normal pancreas. The incidence of PAP overexpression was significantly higher in pancreatic cancer than in the other pancreatic diseases (P < 0.01). PAP overexpression was significantly correlated with nodal involvement, distant metastasis (P < 0.05), and short survival (P < 0.01) in pancreatic cancer. These results suggest that overexpression of PAP in human pancreatic ductal adenocarcinoma indicates tumor aggressiveness.
- Subjects :
- Pancreatic duct
Pathology
medicine.medical_specialty
Pancreatic disease
Physiology
business.industry
Gastroenterology
medicine.disease
female genital diseases and pregnancy complications
medicine.anatomical_structure
Pancreatic cancer
medicine
Adenocarcinoma
Pancreatitis
CA19-9
Pancreatitis-Associated Proteins
Pancreas
business
Subjects
Details
- ISSN :
- 01632116
- Volume :
- 48
- Database :
- OpenAIRE
- Journal :
- Digestive Diseases and Sciences
- Accession number :
- edsair.doi...........8d344aaf363e4a07fb050589d7585c00