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ChemInform Abstract: Isoquinoline Derivatives as Potent CRTH2 Receptor Antagonists: Synthesis and SAR
- Source :
- ChemInform. 43
- Publication Year :
- 2012
- Publisher :
- Wiley, 2012.
-
Abstract
- The most potent compound, TASP0376377 (I) shows good CRTH2 antagonist potency, as well as sufficient selectivity for binding to CRTH2 over the DP1 prostanoid receptor and COX-1 and COX-2 enzymes.
Details
- ISSN :
- 09317597
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- ChemInform
- Accession number :
- edsair.doi...........8cb93fe26ec07de5685ab08f645f274e