Effects of trans ‐10, cis ‐12‐conjugated linoleic acid on mice are influenced by the dietary fat content and the degree of murine obesity

Trans-10, cis-12-conjugated linoleic acid (t10c12-CLA) has been reported to induce body fat loss with the side effects of liver steatosis and the development of diabetes. To investigate whether the dietary fat content may influence the response to t10c12-CLA in animals, t10c12-producing recombinant food-grade Lactococcus lactis transformed with the pai isomerase gene was used to feed lean, obesity-induced, or obese mice. Compared with the non-CLA producing recombinant, the significant (p