Back to Search
Start Over
Assessment of the hand osteoarthritis activity in real clinical practice: possibilities and opportunities
- Source :
- Medical Herald of the South of Russia. 12:70-80
- Publication Year :
- 2021
- Publisher :
- Rostov State Medical University, 2021.
-
Abstract
- Objective: to study the functional disorder, joint structural changes with acute phase parameters, and interleukin-1 beta (IL-1β) in patients with hand osteoarthritis (HOA). Materials and methods: the study included 52 women with HOA, the mean age was 63.4 (10.0) years old. The degree of functional impairment was evaluated according to the visual analogue scale (VAS) and the author’s questionnaire. The laboratory study included an assessment of ESR, C-reactive protein (CRP), and IL-1β levels in the blood. The instrumental diagnostic was performed by X-ray, ultrasonography (US), and magnetic resonance imaging (MRI) of the hand joints. Results: no significant data were obtained on the dependence of the severity of structural and functional disorders from ESR, CRP, and IL-1β levels (rConclusions: there was no correlation between HOA activity and CRP and IL-1β levels but some authors propose to use highly sensitive methods to detect CRP. The application of highly sensitive methods for CRP detection could reveal the association between this indicator and the HOA activity. The absence of dependence between IL-1β level and morpho-functional parameters agrees with the data obtained by other researchers. It is possible that the evaluation of the IL-1β level in dynamics can be useful for assessing the treatment response but this requires further studies.
- Subjects :
- 030203 arthritis & rheumatology
medicine.medical_specialty
Treatment response
medicine.diagnostic_test
biology
business.industry
Visual analogue scale
C-reactive protein
Magnetic resonance imaging
medicine.disease
Gastroenterology
Functional disorder
Hand joint
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
biology.protein
In patient
business
030217 neurology & neurosurgery
Hand osteoarthritis
Subjects
Details
- ISSN :
- 26187876 and 22198075
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Medical Herald of the South of Russia
- Accession number :
- edsair.doi...........8c12c66e37b9824a424ab18ea34a8b41