Biocatalyzed Synthesis of Antidiabetic Drugs

The pancreatic hormone amylin is co-synthesized and co-released with insulin from pancreatic beta-cells, although it is also expressed in the central nervous system, in particular in parts involved in metabolic control, such as the lateral hypo-thalamus. The thioester rac-4 was resolved with Pseudomonas cepacia lipase in the presence of a tert-amine base, trioctylamine. Incretins are gut hormones that potentiate insulin secretion after meal ingestion in a glucose-dependent manner. The G protein-coupled receptor 119, responsive to natural ligands oleoylethanolamide and monooleoylglycerol, is a potential target for the development of oral antidiabetic drugs. Inhibition of enzymes involved in metabolic pathways is undoubtedly one of the most active areas inside Medicinal Chemistry. An increased abnormal concentration of glucocorticoids may lead to its precipitation, with the concomitant aggravation of truncal obesity, insulin resistance, hepatic triacylglycerol accumulation, hyperglycemia, hypertension and dyslipidemia.