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Inhibition of urethane-induced lung carcinogenesis in mice by a Rhizoma paridis saponin involved EGFR/PI3K/Akt pathway
- Source :
- RSC Advances. 6:92330-92334
- Publication Year :
- 2016
- Publisher :
- Royal Society of Chemistry (RSC), 2016.
-
Abstract
- Lung cancer is one of the most common cancers in the world. Due to a lack of successful treatments for lung cancer, there is a need to evaluate new and effective agents for lung cancer treatment. Rhizoma Paridis saponins (RPS) were deemed effective for the treatment of cancer disease. In the present study, we evaluated the role of RPS on urethane-induced lung carcinogenesis in C57BL/6 mice. As a result, the treatment with RPS reduced the severity of the histopathology on urethane-induced lung tumorigenesis in mice. The mechanisms of its antitumor effect involved in (i) reducing oxidative stress injury through up-regulation of Nrf2 and HO-1, (ii) decreasing the level of inflammatory factors, like COX-2 and PGE2, (iii) activation of caspase-3 through the down-regulation of anti-apoptotic protein (Bcl2) and up-regulation of pro-apoptotic protein (Bax), (iv) decreasing the expression of PCNA, and (v) inhibiting the epidermal growth factor receptor (EGFR)/PI3K/Akt pathway. In conclusion, RPS would be a potent agent inhibiting lung cancer in the future.
- Subjects :
- 0301 basic medicine
Lung
biology
business.industry
General Chemical Engineering
Cancer
General Chemistry
respiratory system
medicine.disease
medicine.disease_cause
Proliferating cell nuclear antigen
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
medicine.anatomical_structure
030220 oncology & carcinogenesis
medicine
Cancer research
biology.protein
Epidermal growth factor receptor
Lung cancer
business
Carcinogenesis
PI3K/AKT/mTOR pathway
Oxidative stress
Subjects
Details
- ISSN :
- 20462069
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- RSC Advances
- Accession number :
- edsair.doi...........8bd8768b2c0f236088a863052448e497