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Prolongation of Heterotopic Rat Heart Allograft Survival by ‘Methotrexate-Folinic Acid Rescue
- Source :
- European Surgical Research. 11:331-336
- Publication Year :
- 1979
- Publisher :
- S. Karger AG, 1979.
-
Abstract
- Brown Norway rats received heterotopic (WF/BN) X F1 heart transplants. Functional graft survival time (FST) was 10.0 ± 0.5 days. When the highest tolerable daily dose of methotrexate (25 µg/kg) was given, FST was 26.2 ± 5.6 days. When the highest tolerable dose of methotrexate with ‘folinic acid rescue’ (175 µg/kg) was administered, the FST was found to be 25.3 ± 11.0 days. Folinic acid given between daily methotrexate doses diminished the toxicity of the latter drug but also its therapeutic transplant-protective effectiveness. Methotrexate alone given in multiple nontoxic doses proved to be a strong and safe transplant-protective immunosuppressive agent.
Details
- ISSN :
- 14219921 and 0014312X
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- European Surgical Research
- Accession number :
- edsair.doi...........8ba6274d8aa2340111d548ddf202a060