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Anti-inflammatory effects of the petasin phyto drug Ze339 are mediated by inhibition of the STAT pathway
- Source :
- BioFactors. 43:388-399
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Ze339, an herbal extract from Petasites hybridus leaves is effective in treatment of allergic rhinitis by inhibition of a local production of IL-8 and eicosanoid LTB4 in allergen-challenged patients. However, the mechanism of action and anti-inflammatory potential in virally induced exacerbation of the upper airways is unknown. This study investigates the anti-inflammatory mechanisms of Ze339 on primary human nasal epithelial cells (HNECs) upon viral, bacterial and pro-inflammatory triggers. To investigate the influence of viral and bacterial infections on the airways, HNECs were stimulated with viral mimics, bacterial toll-like-receptor (TLR)-ligands or cytokines, in presence or absence of Ze339. The study uncovers Ze339 modulated changes in pro-inflammatory mediators and decreased neutrophil chemotaxis as well as a reduction of the nuclear translocation and phosphorylation of STAT molecules. Taken together, this study suggests that phyto drug Ze339 specifically targets STAT-signalling pathways in HNECs and has high potential as a broad anti-inflammatory drug that exceeds current indication. © 2016 BioFactors, 43(3):388-399, 2017.
- Subjects :
- 0301 basic medicine
Drug
medicine.drug_class
Petasin
media_common.quotation_subject
Clinical Biochemistry
JAK-STAT signaling pathway
General Medicine
Pharmacology
Biochemistry
Anti-inflammatory
stat
03 medical and health sciences
chemistry.chemical_compound
030104 developmental biology
0302 clinical medicine
030228 respiratory system
Mechanism of action
Eicosanoid
chemistry
medicine
Molecular Medicine
Phosphorylation
medicine.symptom
media_common
Subjects
Details
- ISSN :
- 09516433
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- BioFactors
- Accession number :
- edsair.doi...........8b9280d3993c1675b78bef2be8781758