Evaluation of the anti-inflammatory and antioxidant effects of the microalgae Nannochloropsis gaditana in streptozotocin-induced diabetic rats

This study aims to evaluate the anti-inflammatory and antioxidant effects of N. gaditana on streptozotocin (STZ)-induced diabetes mellitus in Wistar rats. Diabetes was induced in male Wistar rats by single intraperitoneal injection of STZ (45 mg/kg). Male rats were fed on control diet supplemented or not with N. gaditana (10%) for a period of 2 months. At the end of the experiment, biochemical parameters and oxidant/antioxidant markers in liver and pancreas tissues, as well as mitochondria isolated from liver of rats, were determined. It was notice that levels of glucose, glycated hemoglobin (HbA1c), lipid profile, kidney functions and liver enzymes in addition to markers of the inflammatory reactions interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) increased significantly (P