Rational Design of an Artificial Nuclease by Engineering a Hetero-Dinuclear Center of Mg-Heme in Myoglobin

Authors :: Ke-Jie Du
Yonghua Wang
Ge-Bo Wen
Chuan-Wan Wei
Ying-Wu Lin
Hong Yuan
Jia-Jia Lang
Jie Luo
Source :: ACS Catalysis. 10:14359-14365
Publication Year :: 2020
Publisher :: American Chemical Society (ACS), 2020.
Abstract: Design of artificial nucleases is essential in biotechnology and biomedicine, whereas few artificial nucleases can both cleave and degrade DNA molecules. Heme proteins are potential enzymes for DNA...

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