Diarylheptanoids with anti-inflammatory activity from the rhizomes of Pleuranthodium racemigerum (Zingiberaceae)

Three new metabolites, 1-(4′′-Methoxyphenyl)-7-(3′,4′-di-hydroxyphenyl)-(E)-hept-2-ene (1), 1-(4′′-Methoxyphenyl)-7-(3′,4′-di-methoxyphenyl)-(E)-hept-2-ene (2), 1-(4′′-Methoxyphenyl)-7-(4′-methoxyphenyl)-(E)-hept-2-ene (3), and the known diaryl heptanoid (4) were identified following anti-inflammatory activity guided fractionation from the rhizomes of Pleuranthodium racemigerum (Zingiberaceae). These diaryl heptanoids (1 – 4) were evaluated for their inhibitory effects on NO production and downregulation of TNF-α in RAW 264.7 macrophages and N-11 microglial cell lines).