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Glutamate Signaling, Associated With Satellite Glial Cells That Envelop Small Trigeminal Ganglion Neurons Is Highly Involved in the Neuropathic Pain

Authors :
Won Mah
Dong Ho Youn
Yu Shin Kim
Dong Kuk Ahn
Yi Sul Cho
Hyoung-Gon Ko
Yong Chul Bae
Jin Young Bae
Publication Year :
2021
Publisher :
Research Square Platform LLC, 2021.

Abstract

Recent studies implicate glutamate release from satellite glial cells (SGCs) surrounding the primary sensory neurons in the mechanisms of pathologic pain. However, little is known about the population of SGCs in the trigeminal ganglion that is involved in glutamate signaling associated with craniofacial neuropathic pain. To address this issue, we used quantitative analysis of electron microscopic immunogold labeling to investigate the changes in glutamate levels in trigeminal neurons and their enveloping SGCs in a rat model of craniofacial neuropathic pain, chronic constriction injury of inferior alveolar nerve (CCI-ION). The density of immunogold, a measure for glutamate concentration, in the neuronal cell bodies of all sizes, and in the SGCs surrounding them, was significantly higher in rats with CCI-ION than in sham-operated rats. This effect was more pronounced for the small neurons (2.2 times higher) and their SGCs (1.8 times higher) than for the medium and the large neurons and their SGCs, respectively. These findings suggest that each populations of SGCs and their surrounding trigeminal neurons of different type are involved in the glutamate signaling associated with neuropathic pain at a different level.

Details

Database :
OpenAIRE
Accession number :
edsair.doi...........8ad56d549c5fc8d6521a777727a2ece0