A randomized trial of 4-aminopyridine in EA2 and related familial episodic ataxias

{#article-title-2} “A randomized trial of 4-aminopyridine in EA2 and related familial episodic ataxias”1 follows this group's preliminary report on how 4-aminopyridine (4-AP) is one of few compounds that effectively blocks attacks in EA2 patients.1,2 The authors convincingly demonstrate that 4-AP reduces the frequency of attacks, but it would be interesting to know if it modified the severity or duration of the attacks. A …