ChemInform Abstract: Efficient Diastereo- and Enantioselective Synthesis of exo-Nitroprolinates by 1,3-Dipolar Cycloadditions Catalyzed by Chiral Phosphoramidite·Silver(I) Complexes

Chiral complexes formed by privileged phosphoramidites and silver triflate or silver benzoate are excellent catalysts for the general 1,3-dipolar cycloaddition between azomethine ylides generated from alpha-amino acid-derived imino esters and nitroalkenes affording the exo-cycloadducts (4,5-trans-2,5-cis-4-nitroprolinates) with high diastereo- and enantioselectivity at room temperature.