ChemInform Abstract: Enantioselective Carbanion Cyclization of 5-Alkenyl Carbamates Induced by Asymmetric Lithiation with s-Butyllithium/(-)-Sparteine System

Treatment of ( E )-6-phenyl-5-hexenyl carbamates with s -BuLi/(−)-sparteine is shown to afford the trans -1,2-disubstituted cyclopentane derivatives in high % ee, along with the bicyclo[3.1.0]hexanes (bicyclization products).