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A case study of the MAC (masked acyl cyanide) oxyhomologation of N,N-dibenzyl-<scp>l</scp>-phenylalaninal with anti diastereoselectivity: preparation of (2S,3S)-allophenylnorstatin esters
- Source :
- Organic & Biomolecular Chemistry. 20:1769-1781
- Publication Year :
- 2022
- Publisher :
- Royal Society of Chemistry (RSC), 2022.
-
Abstract
- The three-component reaction proceeds with unhindered alcohols in good yield and high anti diastereoselectivity to give protected ester derivatives of (2S,3S)-allophenylnorstatin and provides an expedient access to the amino acid itself.
- Subjects :
- Organic Chemistry
Physical and Theoretical Chemistry
Biochemistry
Subjects
Details
- ISSN :
- 14770539 and 14770520
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Organic & Biomolecular Chemistry
- Accession number :
- edsair.doi...........8980e21b7c7fddbee7e8d4c0a5f51c90
- Full Text :
- https://doi.org/10.1039/d1ob02411f