P0163 X-ray repair cross-complementing group 1 (XRCC1) genetic polymorphisms and cervical cancer risk: A systematic review and meta-analysis

Background We did a systematic review and meta-analysis to assess an association between the X-ray repair cross-complementing group 1 ( XRCC1 ) gene Arg399Gln, Arg194Trp, and Arg280His polymorphisms and risk of cervical cancer. Methods Summary odds ratios (ORs) and 95% confidence intervals (CIs) for XRCC1 polymorphisms and cervical cancer were calculated in a fixed-effects model or a random-effects model when appropriate. Findings Ultimately, nine, five, and two studies were found to be eligible for meta-analyses of Arg399Gln, Arg194Trp, and Arg280His polymorphisms, respectively. Our analysis suggested that the variant genotypes of Arg194Trp were associated with a significantly increased risk of cervical cancer (Trp/Trp vs Arg/Arg, OR 2.21, 95% CI 1.60–3.06; Arg/Trp vs Arg/Arg, OR 1.23, 95% CI 1.02–1.49; dominant model, OR 1.36, 95% CI 1.14–1.63; recessive model, OR 2.06, 95% CI 1.51–2.82). No obvious associations were found for the Arg280His polymorphism or the Arg399Gln polymorphism for all genetic models. In a subgroup analyses by ethnicity/country, a significantly increased risk was observed among Asian women, especially among Chinese. Interpretation This meta-analysis suggests that the Arg194Trp polymorphism may be associated with cervical cancer risk, while the Arg399Gln polymorphism might be a low-penetrant risk factor for cervical cancer only in Asians; there may be no association between the Arg280His polymorphism and cervical cancer risk.