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Enhanced antibacterial properties of orthopedic implants by titanium nanotube surface modification: a review of current techniques
- Source :
- International Journal of Nanomedicine. 14:7217-7236
- Publication Year :
- 2019
- Publisher :
- Informa UK Limited, 2019.
-
Abstract
- Prosthesis-associated infections are one of the main causes of implant failure; thus it is important to enhance the long-term antibacterial ability of orthopedic implants. Titanium dioxide nanotubes (TNTs) are biomaterials with good physicochemical properties and biocompatibility. Owing to their inherent antibacterial and drug-loading ability, the antibacterial application of TNTs has received increasing attention. In this review, the process of TNT anodizing fabrication is summarized. Also, the mechanism and the influencing factors of the antibacterial property of bare TNTs are explored. Furthermore, different antibacterial strategies for carrying drugs, as well as modifications to prolong the antibacterial effect and reduce drug-related toxicity are discussed. In addition, antibacterial systems based on TNTs that can automatically respond to infection are introduced. Finally, the currently faced problems are reviewed and potential solutions are proposed. This review provides new insight on TNT fabrication and summarizes the most advanced antibacterial strategies involving TNTs for the enhancement of long-term antibacterial ability and reduction of toxicity.
- Subjects :
- Antibacterial property
Nanotube
Materials science
Biocompatibility
Organic Chemistry
Biophysics
Pharmaceutical Science
chemistry.chemical_element
Bioengineering
Nanotechnology
02 engineering and technology
General Medicine
Antibacterial effect
010402 general chemistry
021001 nanoscience & nanotechnology
01 natural sciences
0104 chemical sciences
Biomaterials
chemistry
Drug Discovery
Drug delivery
Surface modification
Orthopedic implant
0210 nano-technology
Titanium
Subjects
Details
- ISSN :
- 11782013
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- International Journal of Nanomedicine
- Accession number :
- edsair.doi...........8967c057a6ad5be7637b01c5aacdf988